PittsburghV1, France, Analysis, bibRecord, 000436

Pulmonary Hypertension Due to Left Heart Diseases

Identifieur interne : 000436 ( France/Analysis ); précédent : 000435; suivant : 000437

Pulmonary Hypertension Due to Left Heart Diseases

Auteurs : Jean-Luc Vachiery [Belgique] ; Yochai Adir [Israël] ; Joan Albert Barbera [Espagne] ; Hunter Champion [États-Unis] ; John Gerard Coghlan [Royaume-Uni] ; Vincent Cottin [France] ; Teresa De Marco [États-Unis] ; Nazzareno Galie [Italie] ; Stefano Ghio [Italie] ; J. Simon R. Gibbs [Royaume-Uni] ; Fernando Martinez [États-Unis] ; Marc Semigran [États-Unis] ; Gerald Simonneau [France] ; Athol Wells [Royaume-Uni] ; Werner Seeger [Allemagne]

Source :

Journal of the American College of Cardiology [ 0735-1097 ] ; 2013.

RBID : Pascal:14-0036899

Descripteurs français

Pascal (Inist)
- Hypertension artérielle pulmonaire, Cardiopathie, Pathologie de l'appareil circulatoire, Coeur gauche, Appareil circulatoire, Cardiologie.

English descriptors

KwdEn :
- Cardiology, Cardiovascular disease, Circulatory system, Heart disease, Left heart, Pulmonary hypertension.

Abstract

Pulmonary hypertension (PH), a common complication of left heart diseases (LHD), negatively impacts symptoms, exercise capacity, and outcome. Although the true prevalence of PH-LHD is unknown, a subset of patients might present significant PH that cannot be explained by a passive increase in left-sided filling pressures. The term "out-of-proportion" PH has been used to identify that population without a clear definition, which has been found less than ideal and created confusion. We propose a change in terminology and a new definition of PH due to LHD. We suggest to abandon "out-of-proportion" PH and to distinguish "isolated post-capillary PH" from "post-capillary PH with a pre-capillary component" on the basis of the pressure difference between diastolic pulmonary artery pressure and pulmonary artery wedge pressure. Although there is no validated treatment for PH-LHD, we provide insights into management and discuss completed and randomized trials in this condition. Finally, we provide recommendations for future clinical trials to establish safety and efficacy of novel compounds to target this area of unmet medical need.

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 001042
to stream PascalFrancis, to step Curation: 003560
to stream PascalFrancis, to step Checkpoint: 001419
to stream Main, to step Merge: 006C40
to stream Main, to step Curation: 006853
to stream Main, to step Exploration: 006853
to stream France, to step Extraction: 000436

Links to Exploration step

Pascal:14-0036899

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Pulmonary Hypertension Due to Left Heart Diseases</title>
<author><name sortKey="Vachiery, Jean Luc" sort="Vachiery, Jean Luc" uniqKey="Vachiery J" first="Jean-Luc" last="Vachiery">Jean-Luc Vachiery</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Cardiology, Hôpital Erasme, Université Libre de Bruxelles</s1>
<s2>Brussels</s2>
<s3>BEL</s3>
<sZ>1 aut.</sZ>
</inist:fA14>
<country>Belgique</country>
<placeName><settlement type="city">Bruxelles</settlement>
<region nuts="2">Région de Bruxelles-Capitale</region>
<settlement type="city">Bruxelles</settlement>
</placeName>
<orgName type="university">Université libre de Bruxelles</orgName>
</affiliation>
</author>
<author><name sortKey="Adir, Yochai" sort="Adir, Yochai" uniqKey="Adir Y" first="Yochai" last="Adir">Yochai Adir</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Pulmonary Division, Lady Davis Carmel Medical Center, Faculty of Medicine, The Technion, Institute of Technology</s1>
<s2>Haifa</s2>
<s3>ISR</s3>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>Israël</country>
<wicri:noRegion>Haifa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Barbera, Joan Albert" sort="Barbera, Joan Albert" uniqKey="Barbera J" first="Joan Albert" last="Barbera">Joan Albert Barbera</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Hôspital Clinic-IDIBAPS, University of Barcelona, Network Center of Biomedical Research on Respiratory Diseases (CIBERES)</s1>
<s2>Barcelona</s2>
<s3>ESP</s3>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Champion, Hunter" sort="Champion, Hunter" uniqKey="Champion H" first="Hunter" last="Champion">Hunter Champion</name>
<affiliation wicri:level="2"><inist:fA14 i1="04"><s1>University of Pittsburgh Medical Center Montefiore Hospital</s1>
<s2>Pittsburgh, Pennsylvania</s2>
<s3>USA</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Coghlan, John Gerard" sort="Coghlan, John Gerard" uniqKey="Coghlan J" first="John Gerard" last="Coghlan">John Gerard Coghlan</name>
<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Cardiology Royal Free Hospital</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cottin, Vincent" sort="Cottin, Vincent" uniqKey="Cottin V" first="Vincent" last="Cottin">Vincent Cottin</name>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Hospices Civils de Lyon, Louis Pradel Hospital, Department of Respiratory Diseases, National Reference Center for Rare Pulmonary Diseases, Regional Competence Center for Severe Pulmonary Arterial Hypertension; Claude Bernard University Lyon 1</s1>
<s2>Lyon</s2>
<s3>FRA</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="De Marco, Teresa" sort="De Marco, Teresa" uniqKey="De Marco T" first="Teresa" last="De Marco">Teresa De Marco</name>
<affiliation wicri:level="2"><inist:fA14 i1="07"><s1>University of California, San Francisco</s1>
<s2>San Francisco, California</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Galie, Nazzareno" sort="Galie, Nazzareno" uniqKey="Galie N" first="Nazzareno" last="Galie">Nazzareno Galie</name>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Experimental, Diagnostic and Specialty Medicine-DIMES, Bologna University Hospital</s1>
<s2>Bologna</s2>
<s3>ITA</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Bologna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ghio, Stefano" sort="Ghio, Stefano" uniqKey="Ghio S" first="Stefano" last="Ghio">Stefano Ghio</name>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Divisione di Cardiologia, Fondazione IRCCS Policlinico San Matteo</s1>
<s2>Pavia</s2>
<s3>ITA</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Pavia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gibbs, J Simon R" sort="Gibbs, J Simon R" uniqKey="Gibbs J" first="J. Simon R." last="Gibbs">J. Simon R. Gibbs</name>
<affiliation wicri:level="3"><inist:fA14 i1="10"><s1>National Heart and Lung Institute, Imperial College London and Department of Cardiology, National Pulmonary Hypertension Service, Hammersmith Hospital</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Martinez, Fernando" sort="Martinez, Fernando" uniqKey="Martinez F" first="Fernando" last="Martinez">Fernando Martinez</name>
<affiliation wicri:level="2"><inist:fA14 i1="11"><s1>Division of Pulmonary and Critical Care, University of Michigan Medical Center</s1>
<s2>Ann Arbor, Michigan</s2>
<s3>USA</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Michigan</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Semigran, Marc" sort="Semigran, Marc" uniqKey="Semigran M" first="Marc" last="Semigran">Marc Semigran</name>
<affiliation wicri:level="2"><inist:fA14 i1="12"><s1>MGH Heart Failure and Cardiac Transplantation Center, Massachusetts General Hospital</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Simonneau, Gerald" sort="Simonneau, Gerald" uniqKey="Simonneau G" first="Gerald" last="Simonneau">Gerald Simonneau</name>
<affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Service de Pneumologie, Hôpital Universitaire de Bicêtre, APHP, Université Paris-Sud, Laboratoire d'excellence en recherche sur le medicament et innovation thérapeutique and INSERM</s1>
<s2>Le Kremlin Bicêtre</s2>
<s3>FRA</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion>
<wicri:noRegion>Laboratoire d'excellence en recherche sur le medicament et innovation thérapeutique and INSERM</wicri:noRegion>
<wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wells, Athol" sort="Wells, Athol" uniqKey="Wells A" first="Athol" last="Wells">Athol Wells</name>
<affiliation wicri:level="3"><inist:fA14 i1="14"><s1>Royal Brompton and Harefield NHS Foundation Trust</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Seeger, Werner" sort="Seeger, Werner" uniqKey="Seeger W" first="Werner" last="Seeger">Werner Seeger</name>
<affiliation wicri:level="1"><inist:fA14 i1="15"><s1>University of Giessen and Marburg Lung Center (UGMLC), member of the German Center for Lung Research (DZL), Max-Planck Institute for Heart and Lung Research</s1>
<s2>Giessen/Bad Nauheim</s2>
<s3>DEU</s3>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Giessen/Bad Nauheim</wicri:noRegion>
<wicri:noRegion>Max-Planck Institute for Heart and Lung Research</wicri:noRegion>
<wicri:noRegion>Giessen/Bad Nauheim</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">14-0036899</idno>
<date when="2013">2013</date>
<idno type="stanalyst">PASCAL 14-0036899 INIST</idno>
<idno type="RBID">Pascal:14-0036899</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">001042</idno>
<idno type="wicri:Area/PascalFrancis/Curation">003560</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">001419</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">001419</idno>
<idno type="wicri:doubleKey">0735-1097:2013:Vachiery J:pulmonary:hypertension:due</idno>
<idno type="wicri:Area/Main/Merge">006C40</idno>
<idno type="wicri:Area/Main/Curation">006853</idno>
<idno type="wicri:Area/Main/Exploration">006853</idno>
<idno type="wicri:Area/France/Extraction">000436</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Pulmonary Hypertension Due to Left Heart Diseases</title>
<author><name sortKey="Vachiery, Jean Luc" sort="Vachiery, Jean Luc" uniqKey="Vachiery J" first="Jean-Luc" last="Vachiery">Jean-Luc Vachiery</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Cardiology, Hôpital Erasme, Université Libre de Bruxelles</s1>
<s2>Brussels</s2>
<s3>BEL</s3>
<sZ>1 aut.</sZ>
</inist:fA14>
<country>Belgique</country>
<placeName><settlement type="city">Bruxelles</settlement>
<region nuts="2">Région de Bruxelles-Capitale</region>
<settlement type="city">Bruxelles</settlement>
</placeName>
<orgName type="university">Université libre de Bruxelles</orgName>
</affiliation>
</author>
<author><name sortKey="Adir, Yochai" sort="Adir, Yochai" uniqKey="Adir Y" first="Yochai" last="Adir">Yochai Adir</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Pulmonary Division, Lady Davis Carmel Medical Center, Faculty of Medicine, The Technion, Institute of Technology</s1>
<s2>Haifa</s2>
<s3>ISR</s3>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>Israël</country>
<wicri:noRegion>Haifa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Barbera, Joan Albert" sort="Barbera, Joan Albert" uniqKey="Barbera J" first="Joan Albert" last="Barbera">Joan Albert Barbera</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Hôspital Clinic-IDIBAPS, University of Barcelona, Network Center of Biomedical Research on Respiratory Diseases (CIBERES)</s1>
<s2>Barcelona</s2>
<s3>ESP</s3>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Champion, Hunter" sort="Champion, Hunter" uniqKey="Champion H" first="Hunter" last="Champion">Hunter Champion</name>
<affiliation wicri:level="2"><inist:fA14 i1="04"><s1>University of Pittsburgh Medical Center Montefiore Hospital</s1>
<s2>Pittsburgh, Pennsylvania</s2>
<s3>USA</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Coghlan, John Gerard" sort="Coghlan, John Gerard" uniqKey="Coghlan J" first="John Gerard" last="Coghlan">John Gerard Coghlan</name>
<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Cardiology Royal Free Hospital</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cottin, Vincent" sort="Cottin, Vincent" uniqKey="Cottin V" first="Vincent" last="Cottin">Vincent Cottin</name>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Hospices Civils de Lyon, Louis Pradel Hospital, Department of Respiratory Diseases, National Reference Center for Rare Pulmonary Diseases, Regional Competence Center for Severe Pulmonary Arterial Hypertension; Claude Bernard University Lyon 1</s1>
<s2>Lyon</s2>
<s3>FRA</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="De Marco, Teresa" sort="De Marco, Teresa" uniqKey="De Marco T" first="Teresa" last="De Marco">Teresa De Marco</name>
<affiliation wicri:level="2"><inist:fA14 i1="07"><s1>University of California, San Francisco</s1>
<s2>San Francisco, California</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Galie, Nazzareno" sort="Galie, Nazzareno" uniqKey="Galie N" first="Nazzareno" last="Galie">Nazzareno Galie</name>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Experimental, Diagnostic and Specialty Medicine-DIMES, Bologna University Hospital</s1>
<s2>Bologna</s2>
<s3>ITA</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Bologna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ghio, Stefano" sort="Ghio, Stefano" uniqKey="Ghio S" first="Stefano" last="Ghio">Stefano Ghio</name>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Divisione di Cardiologia, Fondazione IRCCS Policlinico San Matteo</s1>
<s2>Pavia</s2>
<s3>ITA</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Pavia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gibbs, J Simon R" sort="Gibbs, J Simon R" uniqKey="Gibbs J" first="J. Simon R." last="Gibbs">J. Simon R. Gibbs</name>
<affiliation wicri:level="3"><inist:fA14 i1="10"><s1>National Heart and Lung Institute, Imperial College London and Department of Cardiology, National Pulmonary Hypertension Service, Hammersmith Hospital</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Martinez, Fernando" sort="Martinez, Fernando" uniqKey="Martinez F" first="Fernando" last="Martinez">Fernando Martinez</name>
<affiliation wicri:level="2"><inist:fA14 i1="11"><s1>Division of Pulmonary and Critical Care, University of Michigan Medical Center</s1>
<s2>Ann Arbor, Michigan</s2>
<s3>USA</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Michigan</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Semigran, Marc" sort="Semigran, Marc" uniqKey="Semigran M" first="Marc" last="Semigran">Marc Semigran</name>
<affiliation wicri:level="2"><inist:fA14 i1="12"><s1>MGH Heart Failure and Cardiac Transplantation Center, Massachusetts General Hospital</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Simonneau, Gerald" sort="Simonneau, Gerald" uniqKey="Simonneau G" first="Gerald" last="Simonneau">Gerald Simonneau</name>
<affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Service de Pneumologie, Hôpital Universitaire de Bicêtre, APHP, Université Paris-Sud, Laboratoire d'excellence en recherche sur le medicament et innovation thérapeutique and INSERM</s1>
<s2>Le Kremlin Bicêtre</s2>
<s3>FRA</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion>
<wicri:noRegion>Laboratoire d'excellence en recherche sur le medicament et innovation thérapeutique and INSERM</wicri:noRegion>
<wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wells, Athol" sort="Wells, Athol" uniqKey="Wells A" first="Athol" last="Wells">Athol Wells</name>
<affiliation wicri:level="3"><inist:fA14 i1="14"><s1>Royal Brompton and Harefield NHS Foundation Trust</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Seeger, Werner" sort="Seeger, Werner" uniqKey="Seeger W" first="Werner" last="Seeger">Werner Seeger</name>
<affiliation wicri:level="1"><inist:fA14 i1="15"><s1>University of Giessen and Marburg Lung Center (UGMLC), member of the German Center for Lung Research (DZL), Max-Planck Institute for Heart and Lung Research</s1>
<s2>Giessen/Bad Nauheim</s2>
<s3>DEU</s3>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Giessen/Bad Nauheim</wicri:noRegion>
<wicri:noRegion>Max-Planck Institute for Heart and Lung Research</wicri:noRegion>
<wicri:noRegion>Giessen/Bad Nauheim</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Journal of the American College of Cardiology</title>
<title level="j" type="abbreviated">J. Am. Coll. Cardiol.</title>
<idno type="ISSN">0735-1097</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Journal of the American College of Cardiology</title>
<title level="j" type="abbreviated">J. Am. Coll. Cardiol.</title>
<idno type="ISSN">0735-1097</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cardiology</term>
<term>Cardiovascular disease</term>
<term>Circulatory system</term>
<term>Heart disease</term>
<term>Left heart</term>
<term>Pulmonary hypertension</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Hypertension artérielle pulmonaire</term>
<term>Cardiopathie</term>
<term>Pathologie de l'appareil circulatoire</term>
<term>Coeur gauche</term>
<term>Appareil circulatoire</term>
<term>Cardiologie</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Pulmonary hypertension (PH), a common complication of left heart diseases (LHD), negatively impacts symptoms, exercise capacity, and outcome. Although the true prevalence of PH-LHD is unknown, a subset of patients might present significant PH that cannot be explained by a passive increase in left-sided filling pressures. The term "out-of-proportion" PH has been used to identify that population without a clear definition, which has been found less than ideal and created confusion. We propose a change in terminology and a new definition of PH due to LHD. We suggest to abandon "out-of-proportion" PH and to distinguish "isolated post-capillary PH" from "post-capillary PH with a pre-capillary component" on the basis of the pressure difference between diastolic pulmonary artery pressure and pulmonary artery wedge pressure. Although there is no validated treatment for PH-LHD, we provide insights into management and discuss completed and randomized trials in this condition. Finally, we provide recommendations for future clinical trials to establish safety and efficacy of novel compounds to target this area of unmet medical need.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Belgique</li>
<li>Espagne</li>
<li>France</li>
<li>Israël</li>
<li>Italie</li>
<li>Royaume-Uni</li>
<li>États-Unis</li>
</country>
<region><li>Angleterre</li>
<li>Auvergne-Rhône-Alpes</li>
<li>Californie</li>
<li>Catalogne</li>
<li>Grand Londres</li>
<li>Massachusetts</li>
<li>Michigan</li>
<li>Pennsylvanie</li>
<li>Rhône-Alpes</li>
<li>Région de Bruxelles-Capitale</li>
</region>
<settlement><li>Barcelone</li>
<li>Bruxelles</li>
<li>Londres</li>
<li>Lyon</li>
</settlement>
<orgName><li>Université libre de Bruxelles</li>
</orgName>
</list>
<tree><country name="Belgique"><region name="Région de Bruxelles-Capitale"><name sortKey="Vachiery, Jean Luc" sort="Vachiery, Jean Luc" uniqKey="Vachiery J" first="Jean-Luc" last="Vachiery">Jean-Luc Vachiery</name>
</region>
</country>
<country name="Israël"><noRegion><name sortKey="Adir, Yochai" sort="Adir, Yochai" uniqKey="Adir Y" first="Yochai" last="Adir">Yochai Adir</name>
</noRegion>
</country>
<country name="Espagne"><region name="Catalogne"><name sortKey="Barbera, Joan Albert" sort="Barbera, Joan Albert" uniqKey="Barbera J" first="Joan Albert" last="Barbera">Joan Albert Barbera</name>
</region>
</country>
<country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Champion, Hunter" sort="Champion, Hunter" uniqKey="Champion H" first="Hunter" last="Champion">Hunter Champion</name>
</region>
<name sortKey="De Marco, Teresa" sort="De Marco, Teresa" uniqKey="De Marco T" first="Teresa" last="De Marco">Teresa De Marco</name>
<name sortKey="Martinez, Fernando" sort="Martinez, Fernando" uniqKey="Martinez F" first="Fernando" last="Martinez">Fernando Martinez</name>
<name sortKey="Semigran, Marc" sort="Semigran, Marc" uniqKey="Semigran M" first="Marc" last="Semigran">Marc Semigran</name>
</country>
<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Coghlan, John Gerard" sort="Coghlan, John Gerard" uniqKey="Coghlan J" first="John Gerard" last="Coghlan">John Gerard Coghlan</name>
</region>
<name sortKey="Gibbs, J Simon R" sort="Gibbs, J Simon R" uniqKey="Gibbs J" first="J. Simon R." last="Gibbs">J. Simon R. Gibbs</name>
<name sortKey="Wells, Athol" sort="Wells, Athol" uniqKey="Wells A" first="Athol" last="Wells">Athol Wells</name>
</country>
<country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Cottin, Vincent" sort="Cottin, Vincent" uniqKey="Cottin V" first="Vincent" last="Cottin">Vincent Cottin</name>
</region>
<name sortKey="Simonneau, Gerald" sort="Simonneau, Gerald" uniqKey="Simonneau G" first="Gerald" last="Simonneau">Gerald Simonneau</name>
</country>
<country name="Italie"><noRegion><name sortKey="Galie, Nazzareno" sort="Galie, Nazzareno" uniqKey="Galie N" first="Nazzareno" last="Galie">Nazzareno Galie</name>
</noRegion>
<name sortKey="Ghio, Stefano" sort="Ghio, Stefano" uniqKey="Ghio S" first="Stefano" last="Ghio">Stefano Ghio</name>
</country>
<country name="Allemagne"><noRegion><name sortKey="Seeger, Werner" sort="Seeger, Werner" uniqKey="Seeger W" first="Werner" last="Seeger">Werner Seeger</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Amérique/explor/PittsburghV1/Data/France/Analysis

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000436 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/France/Analysis/biblio.hfd -nk 000436 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Amérique
   |area=    PittsburghV1
   |flux=    France
   |étape=   Analysis
   |type=    RBID
   |clé=     Pascal:14-0036899
   |texte=   Pulmonary Hypertension Due to Left Heart Diseases
}}

This area was generated with Dilib version V0.6.38.
Data generation: Fri Jun 18 17:37:45 2021. Site generation: Fri Jun 18 18:15:47 2021

	Serveur d'exploration sur Pittsburgh
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur Pittsburgh

Pulmonary Hypertension Due to Left Heart Diseases

Pulmonary Hypertension Due to Left Heart Diseases

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri